3I6Z

3D Structure of Torpedo californica acetylcholinesterase complexed with N-saccharinohexyl-galanthamine

Summary for 3I6Z

Entry DOI	10.2210/pdb3i6z/pdb
Related	1DX6 1QTI 1W4L 1W6R 1W76 3I6M
Descriptor	Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	serine hydrolase, cholinesterase, neurotransmitter degradation, alzheimer's disease, bis-functional galanthamine derivative, alternative splicing, cell junction, cell membrane, disulfide bond, glycoprotein, gpi-anchor, hydrolase, lipoprotein, membrane, serine esterase, synapse
Biological source	Torpedo californica (Pacific electric ray)
Cellular location	Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
Total number of polymer chains	1
Total formula weight	61631.47
Authors	Lamba, D.,Bartolucci, C. (deposition date: 2009-07-07, release date: 2010-01-12, Last modification date: 2023-09-06)
Primary citation	Bartolucci, C.,Haller, L.A.,Jordis, U.,Fels, G.,Lamba, D. Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives. J.Med.Chem., 53:745-751, 2010 Cited by PubMed: 20025280 DOI: 10.1021/jm901296p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19 Å)

Structure validation