3I6Z

3D Structure of Torpedo californica acetylcholinesterase complexed with N-saccharinohexyl-galanthamine

3I6Z の概要

• エントリーDOI: 10.2210/pdb3i6z/pdb
• 関連するPDBエントリー: 1DX6 1QTI 1W4L 1W6R 1W76 3I6M
• 分子名称: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: serine hydrolase, cholinesterase, neurotransmitter degradation, alzheimer's disease, bis-functional galanthamine derivative, alternative splicing, cell junction, cell membrane, disulfide bond, glycoprotein, gpi-anchor, hydrolase, lipoprotein, membrane, serine esterase, synapse
• 由来する生物種: Torpedo californica (Pacific electric ray)
• 細胞内の位置: Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61631.47

構造登録者

Lamba, D.,Bartolucci, C. (登録日: 2009-07-07, 公開日: 2010-01-12, 最終更新日: 2023-09-06)

• 主引用文献: Bartolucci, C.,Haller, L.A.,Jordis, U.,Fels, G.,Lamba, D.; Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives.; J.Med.Chem., 53:745-751, 2010; PubMed: 20025280; DOI: 10.1021/jm901296p

実験手法

X-RAY DIFFRACTION (2.19 Å)