3I3S

Crystal Structure of H-Ras with Thr50 replaced by Isoleucine

3I3S の概要

• エントリーDOI: 10.2210/pdb3i3s/pdb
• 分子名称: GTPase HRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: gtpases, h-ras, noonan syndrome, cell membrane, disease mutation, golgi apparatus, gtp-binding, lipoprotein, membrane, methylation, nucleotide-binding, palmitate, prenylation, proto-oncogene, s-nitrosylation, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Lipid-anchor; Cytoplasmic side: P01112
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19522.44

構造登録者

Gremer, L.,Dvorsky, R.,Merbitz-Zahradnik, T.,Wittinghofer, A.,Ahmadian, M.R. (登録日: 2009-06-30, 公開日: 2009-12-22, 最終更新日: 2023-09-06)

• 主引用文献: Cirstea, I.C.,Kutsche, K.,Dvorsky, R.,Gremer, L.,Carta, C.,Horn, D.,Roberts, A.E.,Lepri, F.,Merbitz-Zahradnik, T.,Konig, R.,Kratz, C.P.,Pantaleoni, F.,Dentici, M.L.,Joshi, V.A.,Kucherlapati, R.S.,Mazzanti, L.,Mundlos, S.,Patton, M.A.,Silengo, M.C.,Rossi, C.,Zampino, G.,Digilio, C.,Stuppia, L.,Seemanova, E.,Pennacchio, L.A.,Gelb, B.D.,Dallapiccola, B.,Wittinghofer, A.,Ahmadian, M.R.,Tartaglia, M.,Zenker, M.; A restricted spectrum of NRAS mutations causes Noonan syndrome.; Nat.Genet., 42:27-29, 2010; PubMed: 19966803; DOI: 10.1038/ng.497

実験手法

X-RAY DIFFRACTION (1.36 Å)