3I2C

Crystal structure of anti-IL-23 antibody CNTO4088

Summary for 3I2C

• Entry DOI: 10.2210/pdb3i2c/pdb
• Descriptor: CNTO4088 LIGHT CHAIN, CNTO4088 HEAVY CHAIN, GLYCEROL, ... (4 entities in total)
• Functional Keywords: il-23, antibody, fab, immune system
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 2
• Total formula weight: 47950.55

Authors

Teplyakov, A.,Obmolova, G.,Gilliland, G.L. (deposition date: 2009-06-29, release date: 2009-07-07, Last modification date: 2024-10-09)

Primary citation

Teplyakov, A.,Obmolova, G.,Rogers, A.,Gilliland, G.L.
Noncanonical conformation of CDR L1 in the anti-IL-23 antibody CNTO4088.
Acta Crystallogr.,Sect.F, 66:229-232, 2010

PubMed Abstract: CNTO4088 is a monoclonal antibody to human IL-23. The X-ray structure of the Fab fragment revealed an unusual noncanonical conformation of CDR L1. Most antibodies with the kappa light chain exhibit a canonical structure for CDR L1 in which residue 29 anchors the CDR loop to the framework. Analysis of the residues believed to define the conformation of CDR L1 did not explain why it should not adopt a canonical conformation in this antibody. This makes CNTO4088 a benchmark case for developing prediction methods and structure-modeling tools.

PubMed: 20208149
DOI: 10.1107/S1744309109054141

Experimental method

X-RAY DIFFRACTION (2.8 Å)