3I2C

Crystal structure of anti-IL-23 antibody CNTO4088

3I2C の概要

• エントリーDOI: 10.2210/pdb3i2c/pdb
• 分子名称: CNTO4088 LIGHT CHAIN, CNTO4088 HEAVY CHAIN, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: il-23, antibody, fab, immune system
• 由来する生物種: Mus musculus (mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47950.55

構造登録者

Teplyakov, A.,Obmolova, G.,Gilliland, G.L. (登録日: 2009-06-29, 公開日: 2009-07-07, 最終更新日: 2024-10-09)

主引用文献

Teplyakov, A.,Obmolova, G.,Rogers, A.,Gilliland, G.L.
Noncanonical conformation of CDR L1 in the anti-IL-23 antibody CNTO4088.
Acta Crystallogr.,Sect.F, 66:229-232, 2010

PubMed Abstract: CNTO4088 is a monoclonal antibody to human IL-23. The X-ray structure of the Fab fragment revealed an unusual noncanonical conformation of CDR L1. Most antibodies with the kappa light chain exhibit a canonical structure for CDR L1 in which residue 29 anchors the CDR loop to the framework. Analysis of the residues believed to define the conformation of CDR L1 did not explain why it should not adopt a canonical conformation in this antibody. This makes CNTO4088 a benchmark case for developing prediction methods and structure-modeling tools.

PubMed: 20208149
DOI: 10.1107/S1744309109054141

実験手法

X-RAY DIFFRACTION (2.8 Å)