3I0R

crystal structure of HIV reverse transcriptase in complex with inhibitor 3

3I0R の概要

• エントリーDOI: 10.2210/pdb3i0r/pdb
• 関連するPDBエントリー: 3I0S
• 分子名称: Reverse transcriptase/ribonuclease H, p51 RT, S-{2-[(2-chloro-4-sulfamoylphenyl)amino]-2-oxoethyl} 6-methyl-3,4-dihydroquinoline-1(2H)-carbothioate (3 entities in total)
• 機能のキーワード: hiv-1 reverse transcriptase, non-nucleoside inhibition, nucleotidyltrasferase, aids, aspartyl protease, capsid maturation, capsid protein, cell membrane, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, host-virus interaction, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, ribosomal frameshifting, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc, zinc-finger
• 由来する生物種: HIV-1 M:B_HXB2R (HIV-1); 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 117080.70

構造登録者

Yan, Y.,Prasad, S. (登録日: 2009-06-25, 公開日: 2009-08-25, 最終更新日: 2023-09-06)

• 主引用文献: Su, D.S.,Lim, J.J.,Tinney, E.,Wan, B.L.,Young, M.B.,Anderson, K.D.,Rudd, D.,Munshi, V.,Bahnck, C.,Felock, P.J.,Lu, M.,Lai, M.T.,Touch, S.,Moyer, G.,Distefano, D.J.,Flynn, J.A.,Liang, Y.,Sanchez, R.,Prasad, S.,Yan, Y.,Perlow-Poehnelt, R.,Torrent, M.,Miller, M.,Vacca, J.P.,Williams, T.M.,Anthony, N.J.; Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants.; Bioorg.Med.Chem.Lett., 19:5119-5123, 2009; PubMed: 19631528; DOI: 10.1016/j.bmcl.2009.07.031

実験手法

X-RAY DIFFRACTION (2.98 Å)