3HYM
Insights into Anaphase Promoting Complex TPR subdomain assembly from a CDC26-APC6 structure
Summary for 3HYM
| Entry DOI | 10.2210/pdb3hym/pdb |
| Descriptor | Anaphase-promoting complex subunit CDC26, Cell division cycle protein 16 homolog (3 entities in total) |
| Functional Keywords | apc, anaphase promoting complex, cell cycle, mitosis, cyclosome, tpr, ubiquitin, ubiquitin ligase, e3, twinning, alternative splicing, cell division, phosphoprotein, tpr repeat, ubl conjugation pathway, coiled coil, nucleus, ligase |
| Biological source | Homo sapiens (human) More |
| Cellular location | Cytoplasm, cytoskeleton, centrosome: Q8NHZ8 Nucleus (By similarity): Q13042 |
| Total number of polymer chains | 12 |
| Total formula weight | 249117.64 |
| Authors | Wang, J.,Dye, B.T.,Rajashankar, K.R.,Kurinov, I.,Schulman, B.A. (deposition date: 2009-06-22, release date: 2009-08-11, Last modification date: 2011-07-13) |
| Primary citation | Wang, J.,Dye, B.T.,Rajashankar, K.R.,Kurinov, I.,Schulman, B.A. Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure. Nat.Struct.Mol.Biol., 16:987-989, 2009 Cited by PubMed Abstract: The multisubunit anaphase promoting complex (APC) is an essential cell-cycle regulator. Although CDC26 is known to have a role in APC assembly, its molecular function has remained unclear. Biophysical, structural and genetic studies presented here reveal that CDC26 stabilizes the structure of APC6, a core TPR protein required for APC integrity. Notably, CDC26-APC6 association involves an intermolecular TPR mimic composed of one helix from each protein. PubMed: 19668213DOI: 10.1038/nsmb.1645 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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