3HY8

Crystal Structure of Human Pyridoxine 5'-Phosphate Oxidase R229W Mutant

Summary for 3HY8

Entry DOI	10.2210/pdb3hy8/pdb
Descriptor	Pyridoxine-5'-phosphate oxidase, FLAVIN MONONUCLEOTIDE, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
Functional Keywords	fmn binding protein, oxidase, disease mutation, epilepsy, flavoprotein, fmn, oxidoreductase, phosphoprotein, pyridoxal phosphate, pyridoxine biosynthesis
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	31046.44
Authors	Safo, M.K.,Musayev, F.N.,Di Salvo, M.L.,Saavedra, M.K.,Schirch, V. (deposition date: 2009-06-22, release date: 2009-07-28, Last modification date: 2023-09-06)
Primary citation	Musayev, F.N.,Di Salvo, M.L.,Saavedra, M.A.,Contestabile, R.,Ghatge, M.S.,Haynes, A.,Schirch, V.,Safo, M.K. Molecular basis of reduced pyridoxine 5'-phosphate oxidase catalytic activity in neonatal epileptic encephalopathy disorder J.Biol.Chem., 284:30949-30956, 2009 Cited by PubMed: 19759001 DOI: 10.1074/jbc.M109.038372 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation