3HXQ

Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding

3HXQ の概要

• エントリーDOI: 10.2210/pdb3hxq/pdb
• 関連するPDBエントリー: 3HXO
• 分子名称: von Willebrand Factor, Aptamer ARC1172 (3 entities in total)
• 機能のキーワード: arc1779, vwf, platelet glycoprotein ib, aptamer, arc1772, blood coagulation, cell adhesion, cleavage on pair of basic residues, disease mutation, disulfide bond, extracellular matrix, glycoprotein, hemostasis, isopeptide bond, secreted, von willebrand disease, blood clotting-blood clotting regulator complex, blood clotting/blood clotting regulator
• 由来する生物種: Homo sapiens; 詳細
• 細胞内の位置: Secreted : P04275
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36773.82

構造登録者

Huang, R.H.,Sadler, J.E.,Fremont, D.H.,Diener, J.L.,Schaub, R.G. (登録日: 2009-06-21, 公開日: 2009-11-17, 最終更新日: 2023-09-06)

• 主引用文献: Huang, R.H.,Fremont, D.H.,Diener, J.L.,Schaub, R.G.,Sadler, J.E.; A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1.; Structure, 17:1476-1484, 2009; PubMed: 19913482; DOI: 10.1016/j.str.2009.09.011

実験手法

X-RAY DIFFRACTION (2.694 Å)