3HW1

Structure of Bace (beta secretase) in complex with ligand EV2

3HW1 の概要

• エントリーDOI: 10.2210/pdb3hw1/pdb
• 関連するPDBエントリー: 3HVG
• 分子名称: Beta-secretase 1, 3-pyrrolidin-1-ylquinoxalin-2-amine, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: protease, alzheimer's disease, aspartic protease, aspartyl protease, base, beta-secretase, glycoprotein, hydrolase, memapsin 2, amyloid precursor protein secretases, aspartic endopeptidases, fragment-based drug design, fluorescence polarisation, disulfide bond, transmembrane, zymogen
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P56817
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 138118.01

構造登録者

Godemann, R.,Madden, J.,Kramer, J.,Smith, M.A.,Barker, J.,Ebneth, A. (登録日: 2009-06-17, 公開日: 2009-11-03, 最終更新日: 2023-11-01)

• 主引用文献: Godemann, R.,Madden, J.,Kramer, J.,Smith, M.A.,Fritz, U.,Hesterkamp, T.,Barker, J.,Hoeppner, S.,Hallett, D.,Cesura, A.,Ebneth, A.,Kemp, J.; Fragment-Based Discovery of BACE1 Inhibitors Using Functional Assays; Biochemistry, 48:10743-10751, 2009; PubMed: 19799414; DOI: 10.1021/bi901061a

実験手法

X-RAY DIFFRACTION (2.48 Å)