3HQB

Crystal structure of human desarg-C5A

3HQB の概要

• エントリーDOI: 10.2210/pdb3hqb/pdb
• 関連するPDBエントリー: 3HQA
• 分子名称: Complement C5 (1 entity in total)
• 機能のキーワード: complement, c5a, anaphylatoxin, cleavage on pair of basic residues, complement alternate pathway, complement pathway, cytolysis, disulfide bond, glycoprotein, immune response, inflammatory response, innate immunity, membrane attack complex, secreted, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 16323.15

構造登録者

Cook, W.J.,Ealick, S.E. (登録日: 2009-06-05, 公開日: 2010-02-02, 最終更新日: 2024-11-20)

主引用文献

Cook, W.J.,Galakatos, N.,Boyar, W.C.,Walter, R.L.,Ealick, S.E.
Structure of human desArg-C5a.
Acta Crystallogr.,Sect.D, 66:190-197, 2010

PubMed Abstract: The anaphylatoxin C5a is derived from the complement component C5 during activation of the complement cascade. It is an important component in the pathogenesis of a number of inflammatory diseases. NMR structures of human and porcine C5a have been reported; these revealed a four-helix bundle stabilized by three disulfide bonds. The crystal structure of human desArg-C5a has now been determined in two crystal forms. Surprisingly, the protein crystallizes as a dimer and each monomer in the dimer has a three-helix core instead of the four-helix bundle noted in the NMR structure determinations. Furthermore, the N-terminal helices of the two monomers occupy different positions relative to the three-helix core and are completely different from the NMR structures. The physiological significance of these structural differences is unknown.

PubMed: 20124699
DOI: 10.1107/S0907444909049051

実験手法

X-RAY DIFFRACTION (3.299 Å)