3HPT

Crystal structure of human FxA in complex with (S)-2-cyano-1-(2-methylbenzofuran-5-yl)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-yl)guanidine

Summary for 3HPT

Entry DOI	10.2210/pdb3hpt/pdb
Descriptor	Coagulation factor X, GLYCEROL, 1-cyano-2-(2-methyl-1-benzofuran-5-yl)-3-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]guanidine, ... (10 entities in total)
Functional Keywords	serine protease, hydrolase, epidermal growth factor like domain, blood coagulation factor, cleavage on pair of basic residues, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hydroxylation, zymogen, blood clotting, blood coagulation, disulfide bond, protease, secreted
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P00742 P00742
Total number of polymer chains	4
Total formula weight	76648.65
Authors	Klei, H.E.,Ghosh, K.,Rushith, A.,Kish, K. (deposition date: 2009-06-04, release date: 2009-11-17, Last modification date: 2017-11-01)
Primary citation	Shi, Y.,Zhang, J.,Shi, M.,O'Connor, S.P.,Bisaha, S.N.,Li, C.,Sitkoff, D.,Pudzianowski, A.T.,Chong, S.,Klei, H.E.,Kish, K.,Yanchunas, J.,Liu, E.C.,Hartl, K.S.,Seiler, S.M.,Steinbacher, T.E.,Schumacher, W.A.,Atwal, K.S.,Stein, P.D. Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors. Bioorg.Med.Chem.Lett., 19:4034-4041, 2009 Cited by PubMed: 19541481 DOI: 10.1016/j.bmcl.2009.06.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19 Å)

Structure validation