3HOP

Structure of the actin-binding domain of human filamin A

3HOP の概要

• エントリーDOI: 10.2210/pdb3hop/pdb
• 関連するPDBエントリー: 3HOC 3HOR
• 分子名称: Filamin-A, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: calponin homology domain, actin binding domain, acetylation, actin-binding, alternative splicing, cytoplasm, cytoskeleton, disease mutation, phosphoprotein, polymorphism, structural protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cell cortex: P21333
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61195.28

構造登録者

Clark, A.R.,Sawyer, G.M.,Robertson, S.P.,Sutherland-Smith, A.J. (登録日: 2009-06-03, 公開日: 2009-10-13, 最終更新日: 2023-11-01)

• 主引用文献: Clark, A.R.,Sawyer, G.M.,Robertson, S.P.,Sutherland-Smith, A.J.; Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders; Hum.Mol.Genet., 18:4791-4800, 2009; PubMed: 19773341; DOI: 10.1093/hmg/ddp442

実験手法

X-RAY DIFFRACTION (2.3 Å)