3HO0

Crystal structure of the PPARgamma-LBD complexed with a new aryloxy-3phenylpropanoic acid

3HO0 の概要

• エントリーDOI: 10.2210/pdb3ho0/pdb
• 関連するPDBエントリー: 3B3K 3HOD
• 分子名称: Peroxisome proliferator-activated receptor gamma, (2S)-2-(4-phenethylphenoxy)-3-phenyl-propanoic acid (3 entities in total)
• 機能のキーワード: bundle of alpha-helices, small four-stranded beta-sheet, transcription, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription regulation, zinc, zinc-finger
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65407.72

構造登録者

Pochetti, G.,Montanari, R.,Mazza, F.,Loiodice, F.,Fracchiolla, G.,Laghezza, A.,Lavecchia, A.,Novellino, E. (登録日: 2009-06-01, 公開日: 2009-10-27, 最終更新日: 2023-11-01)

• 主引用文献: Fracchiolla, G.,Laghezza, A.,Piemontese, L.,Tortorella, P.,Mazza, F.,Montanari, R.,Pochetti, G.,Lavecchia, A.,Novellino, E.,Pierno, S.,Conte Camerino, D.,Loiodice, F.; New 2-Aryloxy-3-phenyl-propanoic Acids As Peroxisome Proliferator-Activated Receptors alpha/gamma Dual Agonists with Improved Potency and Reduced Adverse Effects on Skeletal Muscle Function; J.Med.Chem., 52:6382-6393, 2009; PubMed: 19775169; DOI: 10.1021/jm900941b

実験手法

X-RAY DIFFRACTION (2.6 Å)