3HNY
Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor
3HNY の概要
エントリーDOI | 10.2210/pdb3hny/pdb |
分子名称 | Coagulation factor VIII (2 entities in total) |
機能のキーワード | blood clotting, acute phase, blood coagulation, calcium, disease mutation, disulfide bond, glycoprotein, hemophilia, metal-binding, pharmaceutical, polymorphism, secreted, sulfation |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Secreted, extracellular space: P00451 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 18029.56 |
構造登録者 | |
主引用文献 | Liu, Z.,Lin, L.,Yuan, C.,Nicolaes, G.A.,Chen, L.,Meehan, E.J.,Furie, B.,Furie, B.,Huang, M. Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. J.Biol.Chem., 285:8824-8829, 2010 Cited by PubMed: 20089867DOI: 10.1074/jbc.M109.080168 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.07 Å) |
構造検証レポート
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