3HLW

CTX-M-9 S70G in complex with cefotaxime

Summary for 3HLW

Entry DOI	10.2210/pdb3hlw/pdb
Descriptor	CTX-M-9 extended-spectrum beta-lactamase, (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-8-oxo-5-thia-1-azabicy clo[4.2.0]oct-2-ene-2-carboxylic acid (3 entities in total)
Functional Keywords	beta-lactamase, esbl, ctx-m, ctx-m-9, beta-lactam, cephalosporin, cefotaxime, michaelis, complex, antibiotic resistance, hydrolase
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	57706.79
Authors	Delmas, J.,Leyssne, D.,Dubois, D.,Vazeille, E.,Robin, F.,Bonnet, R. (deposition date: 2009-05-28, release date: 2010-06-02, Last modification date: 2023-11-01)
Primary citation	Delmas, J.,Leyssene, D.,Dubois, D.,Birck, C.,Vazeille, E.,Robin, F.,Bonnet, R. Structural insights into substrate recognition and product expulsion in CTX-M enzymes. J.Mol.Biol., 400:108-120, 2010 Cited by PubMed: 20452359 DOI: 10.1016/j.jmb.2010.04.062 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation