3HLM

Crystal Structure of Mouse Mitochondrial Aspartate Aminotransferase/Kynurenine Aminotransferase IV

3HLM の概要

• エントリーDOI: 10.2210/pdb3hlm/pdb
• 分子名称: Aspartate aminotransferase, mitochondrial, GLYCEROL (3 entities in total)
• 機能のキーワード: alpha & beta protein, plp-dependent transferase, aminotransferase, multifunctional enzyme, pyridoxal phosphate, acetylation, cell membrane, lipid transport, membrane, mitochondrion, nitration, phosphoprotein, transferase, transit peptide, transport
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Mitochondrion matrix: P05202
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 180016.94

構造登録者

Han, Q.,Robinson, H.,Li, J. (登録日: 2009-05-27, 公開日: 2010-06-02, 最終更新日: 2023-11-22)

主引用文献

Han, Q.,Cai, T.,Tagle, D.A.,Li, J.
Structure, expression, and function of kynurenine aminotransferases in human and rodent brains.
Cell.Mol.Life Sci., 67:353-368, 2010

PubMed Abstract: Kynurenine aminotransferases (KATs) catalyze the synthesis of kynurenic acid (KYNA), an endogenous antagonist of N-methyl-D: -aspartate and alpha 7-nicotinic acetylcholine receptors. Abnormal KYNA levels in human brains are implicated in the pathophysiology of schizophrenia, Alzheimer's disease, and other neurological disorders. Four KATs have been reported in mammalian brains, KAT I/glutamine transaminase K/cysteine conjugate beta-lyase 1, KAT II/aminoadipate aminotransferase, KAT III/cysteine conjugate beta-lyase 2, and KAT IV/glutamic-oxaloacetic transaminase 2/mitochondrial aspartate aminotransferase. KAT II has a striking tertiary structure in N-terminal part and forms a new subgroup in fold type I aminotransferases, which has been classified as subgroup Iepsilon. Knowledge regarding KATs is vast and complex; therefore, this review is focused on recent important progress of their gene characterization, physiological and biochemical function, and structural properties. The biochemical differences of four KATs, specific enzyme activity assays, and the structural insights into the mechanism of catalysis and inhibition of these enzymes are discussed.

PubMed: 19826765
DOI: 10.1007/s00018-009-0166-4

実験手法

X-RAY DIFFRACTION (2.5 Å)