3HLJ

Crystal structure of human carbonic anhydrase isozyme II with 3-methylthiobenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide

3HLJ の概要

• エントリーDOI: 10.2210/pdb3hlj/pdb
• 分子名称: Carbonic anhydrase 2, 3-methylthiobenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide, SODIUM ION, ... (6 entities in total)
• 機能のキーワード: drug design, carbonic anhydrase, sulfonamide, thiadiazole, lyase, disease mutation, metal-binding
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29677.84

構造登録者

Grazulis, S.,Manakova, E.,Golovenko, D. (登録日: 2009-05-27, 公開日: 2010-03-02, 最終更新日: 2023-11-01)

• 主引用文献: Baranauskiene, L.,Hilvo, M.,Matuliene, J.,Golovenko, D.,Manakova, E.,Dudutiene, V.,Michailoviene, V.,Torresan, J.,Jachno, J.,Parkkila, S.,Maresca, A.,Supuran, C.T.,Grazulis, S.,Matulis, D.; Inhibition and binding studies of carbonic anhydrase isozymes I, II and IX with benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulphonamides; J Enzyme Inhib Med Chem, 25:863-870, 2010; PubMed: 20166809; DOI: 10.3109/14756360903571685

実験手法

X-RAY DIFFRACTION (1.44 Å)