3HLG

Simvastatin Synthase (LovD), from Aspergillus terreus, S5 mutant, S76A mutant, complex with lovastatin

Summary for 3HLG

• Entry DOI: 10.2210/pdb3hlg/pdb
• Related: 3HLF
• Descriptor: Transesterase, (3R,5R)-7-((1R,2R,6S,8R,8AS)-2,6-DIMETHYL-8-{[(2R)-2-METHYLBUTANOYL]OXY}-1,2,6,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL)-3,5-DIHYDROXYHEPTANOIC ACID (3 entities in total)
• Functional Keywords: alpha/beta hydrolase fold, transferase
• Biological source: Aspergillus terreus
• Total number of polymer chains: 1
• Total formula weight: 48570.22

Authors

Sawaya, M.R.,Yeates, T.O.,Pashkov, I.,Gao, X.,Tang, Y. (deposition date: 2009-05-27, release date: 2009-10-27, Last modification date: 2023-09-06)

• Primary citation: Gao, X.,Xie, X.,Pashkov, I.,Sawaya, M.R.,Laidman, J.,Zhang, W.,Cacho, R.,Yeates, T.O.,Tang, Y.; Directed evolution and structural characterization of a simvastatin synthase; Chem.Biol., 16:1064-1074, 2009; PubMed: 19875080; DOI: 10.1016/j.chembiol.2009.09.017

Experimental method

X-RAY DIFFRACTION (2.01 Å)