3HJ0

Transthyretin in complex with a covalent small molecule kinetic stabilizer

3HJ0 の概要

• エントリーDOI: 10.2210/pdb3hj0/pdb
• 関連するPDBエントリー: 3CN1 3CN2 3CN3 3CN4
• 分子名称: Transthyretin, 4-fluorophenyl 3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoate (3 entities in total)
• 機能のキーワード: hormone, growth factor, amyloid, disease mutation, gamma-carboxyglutamic acid, glycoprotein, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02766
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28343.51

構造登録者

Connelly, S.,Wilson, I.A.,Kelly, J.W. (登録日: 2009-05-20, 公開日: 2009-12-22, 最終更新日: 2014-11-19)

• 主引用文献: Choi, S.,Connelly, S.,Reixach, N.,Wilson, I.A.,Kelly, J.W.; Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.; Nat.Chem.Biol., 6:133-139, 2010; PubMed: 20081815; DOI: 10.1038/nchembio.281

実験手法

X-RAY DIFFRACTION (1.34 Å)