Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha

Summary for 3HIZ

DescriptorPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha (2 entities in total)
Functional Keywords4, p110, p85, pi3kca, pi3k, pik3r1, phosphatidilynositol 3, 5-triphosphate, h1047r, atp-binding, disease mutation, kinase, nucleotide-binding, oncogene, polymorphism, transferase, alternative splicing, host-virus interaction, phosphoprotein, sh2 domain, sh3 domain, ubl conjugation, transferase-oncoprotein complex, transferase/oncoprotein
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight172104.12
Amzel, L.M.,Vogelstein, B.,Gabelli, S.B.,Mandelker, D. (deposition date: 2009-05-20, release date: 2009-09-29, Last modification date: 2017-11-01)
Primary citation
Mandelker, D.,Gabelli, S.B.,Schmidt-Kittler, O.,Zhu, J.,Cheong, I.,Huang, C.H.,Kinzler, K.W.,Vogelstein, B.,Amzel, L.M.
A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane.
Proc.Natl.Acad.Sci.USA, 106:16996-17001, 2009
PubMed: 19805105 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0908444106
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.332176.1%14.8%7.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report