3HIZ

Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha

Summary for 3HIZ

Entry DOI	10.2210/pdb3hiz/pdb
Related	3HHM
Descriptor	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha (2 entities in total)
Functional Keywords	p110, p85, pi3kca, pi3k, pik3r1, phosphatidilynositol 3, 4, 5-triphosphate, h1047r, atp-binding, disease mutation, kinase, nucleotide-binding, oncogene, polymorphism, transferase, alternative splicing, host-virus interaction, phosphoprotein, sh2 domain, sh3 domain, ubl conjugation, transferase-oncoprotein complex, transferase/oncoprotein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	172104.12
Authors	Amzel, L.M.,Vogelstein, B.,Gabelli, S.B.,Mandelker, D. (deposition date: 2009-05-20, release date: 2009-09-29, Last modification date: 2023-09-06)
Primary citation	Mandelker, D.,Gabelli, S.B.,Schmidt-Kittler, O.,Zhu, J.,Cheong, I.,Huang, C.H.,Kinzler, K.W.,Vogelstein, B.,Amzel, L.M. A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane. Proc.Natl.Acad.Sci.USA, 106:16996-17001, 2009 Cited by PubMed: 19805105 DOI: 10.1073/pnas.0908444106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation