3HIZ

Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha

3HIZ の概要

• エントリーDOI: 10.2210/pdb3hiz/pdb
• 関連するPDBエントリー: 3HHM
• 分子名称: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha (2 entities in total)
• 機能のキーワード: p110, p85, pi3kca, pi3k, pik3r1, phosphatidilynositol 3, 4, 5-triphosphate, h1047r, atp-binding, disease mutation, kinase, nucleotide-binding, oncogene, polymorphism, transferase, alternative splicing, host-virus interaction, phosphoprotein, sh2 domain, sh3 domain, ubl conjugation, transferase-oncoprotein complex, transferase/oncoprotein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 172104.12

構造登録者

Amzel, L.M.,Vogelstein, B.,Gabelli, S.B.,Mandelker, D. (登録日: 2009-05-20, 公開日: 2009-09-29, 最終更新日: 2023-09-06)

• 主引用文献: Mandelker, D.,Gabelli, S.B.,Schmidt-Kittler, O.,Zhu, J.,Cheong, I.,Huang, C.H.,Kinzler, K.W.,Vogelstein, B.,Amzel, L.M.; A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane.; Proc.Natl.Acad.Sci.USA, 106:16996-17001, 2009; PubMed: 19805105; DOI: 10.1073/pnas.0908444106

実験手法

X-RAY DIFFRACTION (3.3 Å)