3HIZ
Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha
3HIZ の概要
エントリーDOI | 10.2210/pdb3hiz/pdb |
関連するPDBエントリー | 3HHM |
分子名称 | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha (2 entities in total) |
機能のキーワード | p110, p85, pi3kca, pi3k, pik3r1, phosphatidilynositol 3, 4, 5-triphosphate, h1047r, atp-binding, disease mutation, kinase, nucleotide-binding, oncogene, polymorphism, transferase, alternative splicing, host-virus interaction, phosphoprotein, sh2 domain, sh3 domain, ubl conjugation, transferase-oncoprotein complex, transferase/oncoprotein |
由来する生物種 | Homo sapiens (human) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 172104.12 |
構造登録者 | Amzel, L.M.,Vogelstein, B.,Gabelli, S.B.,Mandelker, D. (登録日: 2009-05-20, 公開日: 2009-09-29, 最終更新日: 2023-09-06) |
主引用文献 | Mandelker, D.,Gabelli, S.B.,Schmidt-Kittler, O.,Zhu, J.,Cheong, I.,Huang, C.H.,Kinzler, K.W.,Vogelstein, B.,Amzel, L.M. A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane. Proc.Natl.Acad.Sci.USA, 106:16996-17001, 2009 Cited by PubMed: 19805105DOI: 10.1073/pnas.0908444106 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.3 Å) |
構造検証レポート
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