3HIJ

Crystal structure of dihydrodipicolinate synthase from Bacillus anthracis in complex with its substrate, pyruvate

Summary for 3HIJ

Entry DOI	10.2210/pdb3hij/pdb
Related	1XKY 1XL9
Descriptor	Dihydrodipicolinate synthase, GLYCEROL, SODIUM ION, ... (4 entities in total)
Functional Keywords	lyase, tim barrel, pyruvate, tetramer, amino-acid biosynthesis, diaminopimelate biosynthesis, lysine biosynthesis, schiff base
Biological source	Bacillus anthracis (anthrax,anthrax bacterium)
Cellular location	Cytoplasm (By similarity): Q81WN7
Total number of polymer chains	4
Total formula weight	125780.33
Authors	Voss, J.E.,Scally, S.W.,Dobson, R.C.J.,Perugini, M.A. (deposition date: 2009-05-20, release date: 2009-11-24, Last modification date: 2011-07-13)
Primary citation	Voss, J.E.,Scally, S.W.,Taylor, N.L.,Atkinson, S.C.,Griffin, M.D.,Hutton, C.A.,Parker, M.W.,Alderton, M.R.,Gerrard, J.A.,Dobson, R.C.,Dogovski, C.,Perugini, M.A. Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax. J.Biol.Chem., 285:5188-5195, 2010 Cited by PubMed: 19948665 DOI: 10.1074/jbc.M109.038166 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation