3HIJ

Crystal structure of dihydrodipicolinate synthase from Bacillus anthracis in complex with its substrate, pyruvate

3HIJ の概要

• エントリーDOI: 10.2210/pdb3hij/pdb
• 関連するPDBエントリー: 1XKY 1XL9
• 分子名称: Dihydrodipicolinate synthase, GLYCEROL, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: lyase, tim barrel, pyruvate, tetramer, amino-acid biosynthesis, diaminopimelate biosynthesis, lysine biosynthesis, schiff base
• 由来する生物種: Bacillus anthracis (anthrax,anthrax bacterium)
• 細胞内の位置: Cytoplasm (By similarity): Q81WN7
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 125780.33

構造登録者

Voss, J.E.,Scally, S.W.,Dobson, R.C.J.,Perugini, M.A. (登録日: 2009-05-20, 公開日: 2009-11-24, 最終更新日: 2011-07-13)

• 主引用文献: Voss, J.E.,Scally, S.W.,Taylor, N.L.,Atkinson, S.C.,Griffin, M.D.,Hutton, C.A.,Parker, M.W.,Alderton, M.R.,Gerrard, J.A.,Dobson, R.C.,Dogovski, C.,Perugini, M.A.; Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax.; J.Biol.Chem., 285:5188-5195, 2010; PubMed: 19948665; DOI: 10.1074/jbc.M109.038166

実験手法

X-RAY DIFFRACTION (2.15 Å)