Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin

Summary for 3HHM

DescriptorPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, niSH2 p85alpha, (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE, ... (4 entities in total)
Functional Keywords4, p110, p85, pi3kca, pi3k, pik3r1, phosphatidilynositol 3, 5-triphosphate, wortmannin, h1047r, atp-binding, disease mutation, kinase, nucleotide-binding, oncogene, polymorphism, transferase, transferase-oncoprotein complex, transferase/oncoprotein
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight171985.01
Amzel, L.M.,Vogelstein, B.,Gabelli, S.B.,Mandelker, D. (deposition date: 2009-05-15, release date: 2009-09-29, Last modification date: 2018-09-26)
Primary citation
Mandelker, D.,Gabelli, S.B.,Schmidt-Kittler, O.,Zhu, J.,Cheong, I.,Huang, C.H.,Kinzler, K.W.,Vogelstein, B.,Amzel, L.M.
A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane.
Proc.Natl.Acad.Sci.USA, 106:16996-17001, 2009
PubMed: 19805105 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0908444106
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.303114.5%10.2%9.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution