3HGZ

Crystal structure of human insulin-degrading enzyme in complex with amylin

Summary for 3HGZ

Entry DOI	10.2210/pdb3hgz/pdb
Descriptor	Insulin-degrading enzyme, Islet amyloid polypeptide, ZINC ION, ... (4 entities in total)
Functional Keywords	insulin degrading enzyme, ide, amylin, cystein free, cytoplasm, hydrolase, metal-binding, metalloprotease, polymorphism, protease, zinc, amidation, amyloid, cleavage on pair of basic residues, disulfide bond, hormone, secreted
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14735 Secreted: P10997
Total number of polymer chains	4
Total formula weight	232288.88
Authors	Guo, Q.,Bian, Y.,Tang, W.J. (deposition date: 2009-05-14, release date: 2009-12-08, Last modification date: 2021-10-13)
Primary citation	Guo, Q.,Manolopoulou, M.,Bian, Y.,Schilling, A.B.,Tang, W.J. Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme. J.Mol.Biol., 395:430-443, 2010 Cited by PubMed: 19896952 DOI: 10.1016/j.jmb.2009.10.072 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.91 Å)

Structure validation