3HGZ

Crystal structure of human insulin-degrading enzyme in complex with amylin

3HGZ の概要

• エントリーDOI: 10.2210/pdb3hgz/pdb
• 分子名称: Insulin-degrading enzyme, Islet amyloid polypeptide, ZINC ION, ... (4 entities in total)
• 機能のキーワード: insulin degrading enzyme, ide, amylin, cystein free, cytoplasm, hydrolase, metal-binding, metalloprotease, polymorphism, protease, zinc, amidation, amyloid, cleavage on pair of basic residues, disulfide bond, hormone, secreted
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P14735; Secreted: P10997
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 232288.88

構造登録者

Guo, Q.,Bian, Y.,Tang, W.J. (登録日: 2009-05-14, 公開日: 2009-12-08, 最終更新日: 2021-10-13)

• 主引用文献: Guo, Q.,Manolopoulou, M.,Bian, Y.,Schilling, A.B.,Tang, W.J.; Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.; J.Mol.Biol., 395:430-443, 2010; PubMed: 19896952; DOI: 10.1016/j.jmb.2009.10.072

実験手法

X-RAY DIFFRACTION (2.91 Å)