3HG2

Human alpha-galactosidase catalytic mechanism 1. Empty active site

Summary for 3HG2

Entry DOI	10.2210/pdb3hg2/pdb
Related	1R46 1R47 3HG3 3HG4 3HG5
Descriptor	Alpha-galactosidase A, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	glycoprotein, carbohydrate-binding protein, glycosidase, lysosomal enzyme, (beta/alpha)8 barrel, disease mutation, disulfide bond, hydrolase, lysosome
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	93641.64
Authors	Guce, A.I.,Clark, N.E.,Garman, S.C. (deposition date: 2009-05-13, release date: 2009-11-24, Last modification date: 2023-09-06)
Primary citation	Guce, A.I.,Clark, N.E.,Salgado, E.N.,Ivanen, D.R.,Kulminskaya, A.A.,Brumer, H.,Garman, S.C. Catalytic mechanism of human alpha-galactosidase. J.Biol.Chem., 285:3625-3632, 2010 Cited by PubMed: 19940122 DOI: 10.1074/jbc.M109.060145 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation