3HG2

Human alpha-galactosidase catalytic mechanism 1. Empty active site

3HG2 の概要

• エントリーDOI: 10.2210/pdb3hg2/pdb
• 関連するPDBエントリー: 1R46 1R47 3HG3 3HG4 3HG5
• 分子名称: Alpha-galactosidase A, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: glycoprotein, carbohydrate-binding protein, glycosidase, lysosomal enzyme, (beta/alpha)8 barrel, disease mutation, disulfide bond, hydrolase, lysosome
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 93641.64

構造登録者

Guce, A.I.,Clark, N.E.,Garman, S.C. (登録日: 2009-05-13, 公開日: 2009-11-24, 最終更新日: 2023-09-06)

• 主引用文献: Guce, A.I.,Clark, N.E.,Salgado, E.N.,Ivanen, D.R.,Kulminskaya, A.A.,Brumer, H.,Garman, S.C.; Catalytic mechanism of human alpha-galactosidase.; J.Biol.Chem., 285:3625-3632, 2010; PubMed: 19940122; DOI: 10.1074/jbc.M109.060145

実験手法

X-RAY DIFFRACTION (2.3 Å)