3HEK
HSP90 N-terminal domain in complex with 1-{4-[(2R)-1-(5-chloro-2,4-dihydroxybenzoyl)pyrrolidin-2-yl]benzyl}-3,3-difluoropyrrolidinium
Summary for 3HEK
Entry DOI | 10.2210/pdb3hek/pdb |
Descriptor | Heat shock protein HSP 90-alpha, [(2~{R})-2-[4-[[3,3-bis(fluoranyl)pyrrolidin-1-yl]methyl]phenyl]pyrrolidin-1-yl]-[5-chloranyl-2,4-bis(oxidanyl)phenyl]methanone, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | hsp90, alternative splicing, atp-binding, chaperone, cytoplasm, nucleotide-binding, phosphoprotein, stress response |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P07900 |
Total number of polymer chains | 2 |
Total formula weight | 52134.43 |
Authors | Gajiwala, K.S. (deposition date: 2009-05-08, release date: 2009-09-29, Last modification date: 2024-04-03) |
Primary citation | Cho-Schultz, S.,Patten, M.J.,Huang, B.,Elleraas, J.,Gajiwala, K.S.,Hickey, M.J.,Wang, J.,Mehta, P.P.,Kang, P.,Gehring, M.R.,Kung, P.P.,Sutton, S.C. Solution-phase parallel synthesis of Hsp90 inhibitors J.Comb.Chem., 11:860-874, Cited by PubMed: 19583220DOI: 10.1021/cc900056d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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