3HB5

Binary and ternary crystal structures of a novel inhibitor of 17 beta-HSD type 1: a lead compound for breast cancer therapy

3HB5 の概要

• エントリーDOI: 10.2210/pdb3hb5/pdb
• 関連するPDBエントリー: 3HB4
• 分子名称: Estradiol 17-beta-dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-{[(9beta,14beta,16alpha,17alpha)-3,17-dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide, ... (4 entities in total)
• 機能のキーワード: 17beta-hsd1, cytoplasm, lipid synthesis, nadp, oxidoreductase, polymorphism, steroid biosynthesis
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P14061
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36036.76

構造登録者

Mazumdar, M.,Lin, S.-X. (登録日: 2009-05-04, 公開日: 2009-12-15, 最終更新日: 2024-02-21)

• 主引用文献: Mazumdar, M.,Fournier, D.,Zhu, D.W.,Cadot, C.,Poirier, D.,Lin, S.X.; Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy.; Biochem.J., 424:357-366, 2009; PubMed: 19929851; DOI: 10.1042/BJ20091020

実験手法

X-RAY DIFFRACTION (2 Å)