3HB4

17beta-hydroxysteroid dehydrogenase type1 complexed with E2B

Summary for 3HB4

• Entry DOI: 10.2210/pdb3hb4/pdb
• Related: 3HB5
• Descriptor: Estradiol 17-beta-dehydrogenase 1, 3-{[(9beta,14beta,16alpha,17alpha)-3,17-dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide (3 entities in total)
• Functional Keywords: 17betahsd1, cytoplasm, lipid synthesis, nadp, oxidoreductase, polymorphism, steroid biosynthesis
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14061
• Total number of polymer chains: 1
• Total formula weight: 35293.36

Authors

Mazumdar, M.,Fournier, D.,Zhu, D.-W.,Cadot, C.,Poirier, D.,Lin, S.-X. (deposition date: 2009-05-04, release date: 2009-12-15, Last modification date: 2024-02-21)

• Primary citation: Mazumdar, M.,Fournier, D.,Zhu, D.W.,Cadot, C.,Poirier, D.,Lin, S.X.; Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy.; Biochem.J., 424:357-366, 2009; PubMed: 19929851; DOI: 10.1042/BJ20091020

Experimental method

X-RAY DIFFRACTION (2.21 Å)