3HAC
The structure of DPP-4 in complex with piperidine fused imidazopyridine 34
Summary for 3HAC
| Entry DOI | 10.2210/pdb3hac/pdb |
| Related | 3HAB |
| Descriptor | Dipeptidyl peptidase 4 soluble form, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
| Functional Keywords | alpha/beta, beta-propeller, dimer, hydrolase, diabetes, aminopeptidase, cell membrane, disulfide bond, glycoprotein, membrane, protease, secreted, serine protease, signal-anchor, transmembrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 174317.32 |
| Authors | Scapin, G. (deposition date: 2009-05-01, release date: 2009-07-21, Last modification date: 2023-09-20) |
| Primary citation | Edmondson, S.D.,Mastracchio, A.,Cox, J.M.,Eiermann, G.J.,He, H.,Lyons, K.A.,Patel, R.A.,Patel, S.B.,Petrov, A.,Scapin, G.,Wu, J.K.,Xu, S.,Zhu, B.,Thornberry, N.A.,Roy, R.S.,Weber, A.E. Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors Bioorg.Med.Chem.Lett., 19:4097-4101, 2009 Cited by PubMed Abstract: A new series of DPP-4 inhibitors derived from piperidine-fused benzimidazoles and imidazopyridines is described. Optimization of this class of DPP-4 inhibitors led to the discovery of imidazopyridine 34. The potency, selectivity, cross-species DMPK profiles, and in vivo efficacy of 34 is reported. PubMed: 19539471DOI: 10.1016/j.bmcl.2009.06.011 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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