3HA6

Crystal structure of aurora A in complex with TPX2 and compound 10

Summary for 3HA6

• Entry DOI: 10.2210/pdb3ha6/pdb
• Related: 3HA8
• Descriptor: Serine/threonine-protein kinase 6, Targeting protein for Xklp2, N~2~-(3,4-dimethoxyphenyl)-N~4~-[2-(2-fluorophenyl)ethyl]-N~6~-quinolin-6-yl-1,3,5-triazine-2,4,6-triamine, ... (4 entities in total)
• Functional Keywords: aurora a, serine/threonine-protein kinase, cofactor, tpx2, inhibitor, phosphorylation, atp-binding, cell cycle, nucleotide-binding, phosphoprotein, transferase, nucleus, kinase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm, cytoskeleton, centrosome: O14965; Nucleus: Q9ULW0
• Total number of polymer chains: 2
• Total formula weight: 36749.42

Authors

Zhao, B.,Clark, M.A. (deposition date: 2009-05-01, release date: 2009-08-04, Last modification date: 2011-07-13)

• Primary citation: Clark, M.A.,Acharya, R.A.,Arico-Muendel, C.C.,Belyanskaya, S.L.,Benjamin, D.R.,Carlson, N.R.,Centrella, P.A.,Chiu, C.H.,Creaser, S.P.,Cuozzo, J.W.,Davie, C.P.,Ding, Y.,Franklin, G.J.,Franzen, K.D.,Gefter, M.L.,Hale, S.P.,Hansen, N.J.,Israel, D.I.,Jiang, J.,Kavarana, M.J.,Kelley, M.S.,Kollmann, C.S.,Li, F.,Lind, K.,Mataruse, S.,Medeiros, P.F.,Messer, J.A.,Myers, P.,O'Keefe, H.,Oliff, M.C.,Rise, C.E.,Satz, A.L.,Skinner, S.R.,Svendsen, J.L.,Tang, L.,van Vloten, K.,Wagner, R.W.,Yao, G.,Zhao, B.,Morgan, B.A.; Design, synthesis and selection of DNA-encoded small-molecule libraries.; Nat.Chem.Biol., 5:647-654, 2009; PubMed: 19648931; DOI: 10.1038/nchembio.211

Experimental method

X-RAY DIFFRACTION (2.36 Å)