3H9Y

Crystal structure of the IgE-Fc3-4 domains

3H9Y の概要

• エントリーDOI: 10.2210/pdb3h9y/pdb
• 関連するPDBエントリー: 1F6A 1FP5 1O0V 3H9Z 3HA0
• 分子名称: Ig epsilon chain C region, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: immunoglobin, ige, fc, flexibility, hydrophobic pocket, disulfide bond, glycoprotein, immunoglobulin c region, immunoglobulin domain, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted : P01854
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 77673.09

構造登録者

Wurzburg, B.A. (登録日: 2009-04-30, 公開日: 2009-09-08, 最終更新日: 2024-11-27)

主引用文献

Wurzburg, B.A.,Jardetzky, T.S.
Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms.
J.Mol.Biol., 393:176-190, 2009

PubMed Abstract: The structure of immunoglobulin E (IgE)-Fc(3-4) has been solved in three new crystal forms, providing 13 snapshots of the Fc conformation and revealing a diverse range of open-closed motions among subunit chains and dimers. A more detailed analysis of the open-to-closed motion of IgE-Fc(3-4) was possible with so many structures, and the new structures allow a more thorough examination of the flexibility of IgE-Fc and its implications for receptor binding. The existence of a hydrophobic pocket at the elbow region of the Fc appears to be conformation dependent and suggests a means of regulating the IgE-Fc conformation (and potentially receptor binding) with small molecules.

PubMed: 19682998
DOI: 10.1016/j.jmb.2009.08.012

実験手法

X-RAY DIFFRACTION (2.23 Å)