3H9R

Crystal structure of the kinase domain of type I activin receptor (ACVR1) in complex with FKBP12 and dorsomorphin

Summary for 3H9R

• Entry DOI: 10.2210/pdb3h9r/pdb
• Descriptor: Activin receptor type-1, Peptidyl-prolyl cis-trans isomerase FKBP1A, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, ... (6 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, atp-binding, disease mutation, glycoprotein, kinase, magnesium, manganese, membrane, metal-binding, nucleotide-binding, phosphoprotein, receptor, serine/threonine-protein kinase, transferase, transmembrane, isomerase, rotamase, isomerase-protein kinase complex, isomerase/protein kinase
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: Q04771; Cytoplasm: P62942
• Total number of polymer chains: 2
• Total formula weight: 50916.01

Authors

Chaikuad, A.,Alfano, I.,Shrestha, B.,Muniz, J.R.C.,Petrie, K.,Fedorov, O.,Phillips, C.,Bishop, S.,Mahajan, P.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2009-04-30, release date: 2009-06-02, Last modification date: 2023-09-06)

• Primary citation: Chaikuad, A.,Alfano, I.,Kerr, G.,Sanvitale, C.E.,Boergermann, J.H.,Triffitt, J.T.,von Delft, F.,Knapp, S.,Knaus, P.,Bullock, A.N.; Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva.; J.Biol.Chem., 287:36990-36998, 2012; PubMed: 22977237; DOI: 10.1074/jbc.M112.365932

Experimental method

X-RAY DIFFRACTION (2.35 Å)