3H8C

A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors (compound 14)

3H8C の概要

• エントリーDOI: 10.2210/pdb3h8c/pdb
• 関連するPDBエントリー: 3H89 3H8B
• 分子名称: Cathepsin L1, N-(biphenyl-4-ylacetyl)-S-methyl-L-cysteinyl-D-arginyl-N-(2-phenylethyl)-L-phenylalaninamide (3 entities in total)
• 機能のキーワード: cysteine proteases, cathepsin l, disulfide bond, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: P07711
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49919.28

構造登録者

Tulsidas, S.R.,Chowdhury, S.F.,Kumar, S.,Joseph, L.,Purisima, E.O.,Sivaraman, J. (登録日: 2009-04-29, 公開日: 2009-10-20, 最終更新日: 2014-11-12)

• 主引用文献: Shenoy, R.T.,Chowdhury, S.F.,Kumar, S.,Joseph, L.,Purisima, E.O.,Sivaraman, J.; A Combined Crystallographic and Molecular Dynamics Study of Cathepsin L Retrobinding Inhibitors; J.Med.Chem., 2009; PubMed: 19761244; DOI: 10.1021/jm900596y

実験手法

X-RAY DIFFRACTION (2.5 Å)