3H6K

Crystal Structure of Human 11-beta-hydroxysteroid-dehydrogenase Bound to an Ortho-chlro-sulfonyl-piperazine Inhibitor

3H6K の概要

• エントリーDOI: 10.2210/pdb3h6k/pdb
• 分子名称: Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-chloro-4-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)benzamide, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, hsd1, nadp, inhibitor, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, polymorphism, signal-anchor, steroid metabolism, transmembrane
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 132240.62

構造登録者

Bard, J.,Svenson, K. (登録日: 2009-04-23, 公開日: 2009-12-01, 最終更新日: 2024-02-21)

• 主引用文献: Wan, Z.K.,Chenail, E.,Xiang, J.,Li, H.Q.,Ipek, M.,Bard, J.,Svenson, K.,Mansour, T.S.,Xu, X.,Tian, X.,Suri, V.,Hahm, S.,Xing, Y.,Johnson, C.E.,Li, X.,Qadri, A.,Panza, D.,Perreault, M.,Tobin, J.F.,Saiah, E.; Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.; J.Med.Chem., 52:5449-5461, 2009; PubMed: 19673466; DOI: 10.1021/jm900639u

実験手法

X-RAY DIFFRACTION (2.187 Å)