3H5Z

Crystal Structure of Leishmania major N-myristoyltransferase with bound myristoyl-CoA

3H5Z の概要

• エントリーDOI: 10.2210/pdb3h5z/pdb
• 分子名称: Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: transferase, n-myristoyltransferase, nmt, leishmania major, structural genomics, structural genomics consortium, sgc, acyltransferase
• 由来する生物種: Leishmania major
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51553.21

構造登録者

Qiu, W.,Hutchinson, A.,Lin, Y.-H.,Wernimont, A.,Mackenzie, F.,Ravichandran, M.,Cossar, D.,Zhao, Y.,Schapira, M.,Arrowsmith, C.H.,Bountra, C.,Weigelt, J.,Edwards, A.M.,Ferguson, M.A.J.,Fairlamb, A.H.,Hui, R.,Structural Genomics Consortium (SGC) (登録日: 2009-04-22, 公開日: 2009-05-12, 最終更新日: 2023-09-06)

• 主引用文献: Frearson, J.A.,Brand, S.,McElroy, S.P.,Cleghorn, L.A.,Smid, O.,Stojanovski, L.,Price, H.P.,Guther, M.L.,Torrie, L.S.,Robinson, D.A.,Hallyburton, I.,Mpamhanga, C.P.,Brannigan, J.A.,Wilkinson, A.J.,Hodgkinson, M.,Hui, R.,Qiu, W.,Raimi, O.G.,van Aalten, D.M.,Brenk, R.,Gilbert, I.H.,Read, K.D.,Fairlamb, A.H.,Ferguson, M.A.,Smith, D.F.,Wyatt, P.G.; N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.; Nature, 464:728-732, 2010; PubMed: 20360736; DOI: 10.1038/nature08893

実験手法

X-RAY DIFFRACTION (1.49 Å)