3H3B

Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain

Summary for 3H3B

• Entry DOI: 10.2210/pdb3h3b/pdb
• Descriptor: Receptor tyrosine-protein kinase erbB-2, anti-ErbB2 antibody chA21 (3 entities in total)
• Functional Keywords: immunoglobulin, beta-helix, protein-protein complex, atp-binding, disulfide bond, kinase, nucleotide-binding, receptor, transferase, transmembrane, tyrosine-protein kinase, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626
• Total number of polymer chains: 4
• Total formula weight: 98458.05

Authors

Zhou, H.,Liu, Y.,Niu, L.,Zhu, J.,Teng, M. (deposition date: 2009-04-16, release date: 2010-04-28, Last modification date: 2023-11-01)

• Primary citation: Zhou, H.,Zha, Z.,Liu, Y.,Zhang, H.,Zhu, J.,Hu, S.,Shen, G.,Cheng, L.,Niu, L.,Greene, M.I.,Teng, M.,Liu, J.; Structural Insights into the Down-regulation of Overexpressed p185her2/neu Protein of Transformed Cells by the Antibody chA21.; J.Biol.Chem., 286:31676-31683, 2011; PubMed: 21680730; DOI: 10.1074/jbc.M111.235184

Experimental method

X-RAY DIFFRACTION (2.45 Å)