3H3B
Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain
Summary for 3H3B
Entry DOI | 10.2210/pdb3h3b/pdb |
Descriptor | Receptor tyrosine-protein kinase erbB-2, anti-ErbB2 antibody chA21 (3 entities in total) |
Functional Keywords | immunoglobulin, beta-helix, protein-protein complex, atp-binding, disulfide bond, kinase, nucleotide-binding, receptor, transferase, transmembrane, tyrosine-protein kinase, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626 |
Total number of polymer chains | 4 |
Total formula weight | 98458.05 |
Authors | |
Primary citation | Zhou, H.,Zha, Z.,Liu, Y.,Zhang, H.,Zhu, J.,Hu, S.,Shen, G.,Cheng, L.,Niu, L.,Greene, M.I.,Teng, M.,Liu, J. Structural Insights into the Down-regulation of Overexpressed p185her2/neu Protein of Transformed Cells by the Antibody chA21. J.Biol.Chem., 286:31676-31683, 2011 Cited by PubMed: 21680730DOI: 10.1074/jbc.M111.235184 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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