3H0A

Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (PPARg) and Retinoic Acid Receptor Alpha (RXRa) in Complex with 9-cis Retinoic Acid, Co-activator Peptide, and a Partial Agonist

Summary for 3H0A

Entry DOI	10.2210/pdb3h0a/pdb
Descriptor	Retinoic acid receptor RXR-alpha, Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, Co-activator Peptide, ... (6 entities in total)
Functional Keywords	ppar, transcription, nuclear receptor fold, transcription regulation, hormone, growth factor receptor, complex, dna-binding, host-virus interaction, isopeptide bond, metal-binding, nucleus, receptor, zinc-finger, activator, diabetes mellitus, disease mutation, obesity, phosphoprotein, acyltransferase, proto-oncogene, transferase
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus: P19793 P37231 Nucleus (By similarity): Q15788
Total number of polymer chains	4
Total formula weight	60300.08
Authors	Wang, Z.,Sudom, A.,Walker, N.P. (deposition date: 2009-04-08, release date: 2009-06-09, Last modification date: 2024-02-21)
Primary citation	Connors, R.V.,Wang, Z.,Harrison, M.,Zhang, A.,Wanska, M.,Hiscock, S.,Fox, B.,Dore, M.,Labelle, M.,Sudom, A.,Johnstone, S.,Liu, J.,Walker, N.P.,Chai, A.,Siegler, K.,Li, Y.,Coward, P. Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma. Bioorg.Med.Chem.Lett., 19:3550-3554, 2009 Cited by PubMed Abstract: The discovery and optimization of a series of potent PPARdelta full agonists with partial agonistic activity against PPARgamma is described. PubMed: 19464171 DOI: 10.1016/j.bmcl.2009.04.151 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation