3H0A

Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (PPARg) and Retinoic Acid Receptor Alpha (RXRa) in Complex with 9-cis Retinoic Acid, Co-activator Peptide, and a Partial Agonist

3H0A の概要

• エントリーDOI: 10.2210/pdb3h0a/pdb
• 分子名称: Retinoic acid receptor RXR-alpha, Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, Co-activator Peptide, ... (6 entities in total)
• 機能のキーワード: ppar, transcription, nuclear receptor fold, transcription regulation, hormone, growth factor receptor, complex, dna-binding, host-virus interaction, isopeptide bond, metal-binding, nucleus, receptor, zinc-finger, activator, diabetes mellitus, disease mutation, obesity, phosphoprotein, acyltransferase, proto-oncogene, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus: P19793 P37231; Nucleus (By similarity): Q15788
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 60300.08

構造登録者

Wang, Z.,Sudom, A.,Walker, N.P. (登録日: 2009-04-08, 公開日: 2009-06-09, 最終更新日: 2024-02-21)

主引用文献

Connors, R.V.,Wang, Z.,Harrison, M.,Zhang, A.,Wanska, M.,Hiscock, S.,Fox, B.,Dore, M.,Labelle, M.,Sudom, A.,Johnstone, S.,Liu, J.,Walker, N.P.,Chai, A.,Siegler, K.,Li, Y.,Coward, P.
Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.
Bioorg.Med.Chem.Lett., 19:3550-3554, 2009

PubMed Abstract: The discovery and optimization of a series of potent PPARdelta full agonists with partial agonistic activity against PPARgamma is described.

PubMed: 19464171
DOI: 10.1016/j.bmcl.2009.04.151

実験手法

X-RAY DIFFRACTION (2.1 Å)