3H0A
Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (PPARg) and Retinoic Acid Receptor Alpha (RXRa) in Complex with 9-cis Retinoic Acid, Co-activator Peptide, and a Partial Agonist
3H0A の概要
エントリーDOI | 10.2210/pdb3h0a/pdb |
分子名称 | Retinoic acid receptor RXR-alpha, Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, Co-activator Peptide, ... (6 entities in total) |
機能のキーワード | ppar, transcription, nuclear receptor fold, transcription regulation, hormone, growth factor receptor, complex, dna-binding, host-virus interaction, isopeptide bond, metal-binding, nucleus, receptor, zinc-finger, activator, diabetes mellitus, disease mutation, obesity, phosphoprotein, acyltransferase, proto-oncogene, transferase |
由来する生物種 | Homo sapiens (Human) 詳細 |
細胞内の位置 | Nucleus: P19793 P37231 Nucleus (By similarity): Q15788 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 60300.08 |
構造登録者 | |
主引用文献 | Connors, R.V.,Wang, Z.,Harrison, M.,Zhang, A.,Wanska, M.,Hiscock, S.,Fox, B.,Dore, M.,Labelle, M.,Sudom, A.,Johnstone, S.,Liu, J.,Walker, N.P.,Chai, A.,Siegler, K.,Li, Y.,Coward, P. Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma. Bioorg.Med.Chem.Lett., 19:3550-3554, 2009 Cited by PubMed: 19464171DOI: 10.1016/j.bmcl.2009.04.151 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.1 Å) |
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