3GYM

Structure of Prostasin in Complex with Aprotinin

3GYM の概要

• エントリーDOI: 10.2210/pdb3gym/pdb
• 関連するPDBエントリー: 3E1X 3EON 3FVF 3GYL
• 分子名称: Prostasin, Pancreatic trypsin inhibitor (2 entities in total)
• 機能のキーワード: prostasin, hcap1, channel activating, aprotinin, inhibition, disulfide bond, pharmaceutical, protease inhibitor, secreted, serine protease inhibitor, cell membrane, glycoprotein, hydrolase, membrane, protease, serine protease, transmembrane, zymogen, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Prostasin: Cell membrane; Single-pass membrane protein. Prostasin light chain: Secreted, extracellular space. Prostasin heavy chain: Secreted, extracellular space: Q16651; Secreted: P00974
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 69508.24

構造登録者

Spraggon, G.,Hornsby, M.,Shipway, A.,Harris, J.L.,Lesley, S.A. (登録日: 2009-04-03, 公開日: 2009-05-05, 最終更新日: 2023-09-06)

• 主引用文献: Spraggon, G.,Hornsby, M.,Shipway, A.,Tully, D.C.,Bursulaya, B.,Danahay, H.,Harris, J.L.,Lesley, S.A.; Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.; Protein Sci., 18:1081-1094, 2009; PubMed: 19388054; DOI: 10.1002/pro.118

実験手法

X-RAY DIFFRACTION (2.8 Å)