3GYL
Structure of Prostasin at 1.3 Angstroms resolution in complex with a Calcium Ion.
Summary for 3GYL
Entry DOI | 10.2210/pdb3gyl/pdb |
Related | 3E1X 3EON 3FVF |
Descriptor | Prostasin, CALCIUM ION, GLYCEROL, ... (4 entities in total) |
Functional Keywords | prostasin, enac, zymogen, divalent cation, channel activating, cell membrane, disulfide bond, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, transmembrane |
Biological source | Homo sapiens (human) |
Cellular location | Prostasin: Cell membrane; Single-pass membrane protein. Prostasin light chain: Secreted, extracellular space. Prostasin heavy chain: Secreted, extracellular space: Q16651 |
Total number of polymer chains | 1 |
Total formula weight | 28450.82 |
Authors | Spraggon, G.,Hornsby, M.,Shipway, A.,Harris, J.L.,Lesley, S.A. (deposition date: 2009-04-03, release date: 2009-04-21, Last modification date: 2023-09-06) |
Primary citation | Spraggon, G.,Hornsby, M.,Shipway, A.,Tully, D.C.,Bursulaya, B.,Danahay, H.,Harris, J.L.,Lesley, S.A. Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations. Protein Sci., 18:1081-1094, 2009 Cited by PubMed: 19388054DOI: 10.1002/pro.118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
Download full validation report