3GXL

ALK-5 kinase complex with GW857175

3GXL の概要

• エントリーDOI: 10.2210/pdb3gxl/pdb
• 関連するPDBエントリー: 3GXJ
• 分子名称: TGF-beta receptor type-1, N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine (3 entities in total)
• 機能のキーワード: tgf-beta, alk5, kinase, inhibitor, quinazoline, aortic aneurysm, atp-binding, craniosynostosis, disease mutation, disulfide bond, glycoprotein, magnesium, manganese, membrane, metal-binding, nucleotide-binding, phosphoprotein, polymorphism, receptor, serine/threonine-protein kinase, transferase, transmembrane
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : P36897
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35076.38

構造登録者

Smith, W.,Janson, C. (登録日: 2009-04-02, 公開日: 2009-04-21, 最終更新日: 2023-11-01)

• 主引用文献: Gellibert, F.,Fouchet, M.-H.,Nguyen, V.-L.,Wang, R.,Krysa, G.,de Gouville, A.-C.,Huet, S.,Dodic, N.; Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors; Bioorg.Med.Chem.Lett., 19:2277-2281, 2009; PubMed: 19285388; DOI: 10.1016/j.bmcl.2009.02.087

実験手法

X-RAY DIFFRACTION (1.8 Å)