3GWC
Crystal structure of Mycobacterium tuberculosis thymidylate synthase X bound to FdUMP and FAD
Summary for 3GWC
Entry DOI | 10.2210/pdb3gwc/pdb |
Descriptor | Thymidylate synthase thyX, FLAVIN-ADENINE DINUCLEOTIDE, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (5 entities in total) |
Functional Keywords | thyx, fad, fdump, flavoprotein, methyltransferase, nucleotide biosynthesis, transferase, structural genomics, seattle structural genomics center for infectious disease, ssgcid |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 8 |
Total formula weight | 238581.31 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2009-03-31, release date: 2009-04-28, Last modification date: 2024-02-21) |
Primary citation | Baugh, L.,Phan, I.,Begley, D.W.,Clifton, M.C.,Armour, B.,Dranow, D.M.,Taylor, B.M.,Muruthi, M.M.,Abendroth, J.,Fairman, J.W.,Fox, D.,Dieterich, S.H.,Staker, B.L.,Gardberg, A.S.,Choi, R.,Hewitt, S.N.,Napuli, A.J.,Myers, J.,Barrett, L.K.,Zhang, Y.,Ferrell, M.,Mundt, E.,Thompkins, K.,Tran, N.,Lyons-Abbott, S.,Abramov, A.,Sekar, A.,Serbzhinskiy, D.,Lorimer, D.,Buchko, G.W.,Stacy, R.,Stewart, L.J.,Edwards, T.E.,Van Voorhis, W.C.,Myler, P.J. Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95:142-148, 2015 Cited by PubMed: 25613812DOI: 10.1016/j.tube.2014.12.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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