3GWC

Crystal structure of Mycobacterium tuberculosis thymidylate synthase X bound to FdUMP and FAD

3GWC の概要

• エントリーDOI: 10.2210/pdb3gwc/pdb
• 分子名称: Thymidylate synthase thyX, FLAVIN-ADENINE DINUCLEOTIDE, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: thyx, fad, fdump, flavoprotein, methyltransferase, nucleotide biosynthesis, transferase, structural genomics, seattle structural genomics center for infectious disease, ssgcid
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 238581.31

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2009-03-31, 公開日: 2009-04-28, 最終更新日: 2024-02-21)

• 主引用文献: Baugh, L.,Phan, I.,Begley, D.W.,Clifton, M.C.,Armour, B.,Dranow, D.M.,Taylor, B.M.,Muruthi, M.M.,Abendroth, J.,Fairman, J.W.,Fox, D.,Dieterich, S.H.,Staker, B.L.,Gardberg, A.S.,Choi, R.,Hewitt, S.N.,Napuli, A.J.,Myers, J.,Barrett, L.K.,Zhang, Y.,Ferrell, M.,Mundt, E.,Thompkins, K.,Tran, N.,Lyons-Abbott, S.,Abramov, A.,Sekar, A.,Serbzhinskiy, D.,Lorimer, D.,Buchko, G.W.,Stacy, R.,Stewart, L.J.,Edwards, T.E.,Van Voorhis, W.C.,Myler, P.J.; Increasing the structural coverage of tuberculosis drug targets.; Tuberculosis (Edinb), 95:142-148, 2015; PubMed: 25613812; DOI: 10.1016/j.tube.2014.12.003

実験手法

X-RAY DIFFRACTION (1.9 Å)