3GW9
Crystal structure of sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei bound to an inhibitor N-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxaziazol-2-yl)benzamide
Summary for 3GW9
Entry DOI | 10.2210/pdb3gw9/pdb |
Related | 3G1Q |
Descriptor | STEROL 14ALPHA-DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, N-[(1R)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide, ... (4 entities in total) |
Functional Keywords | sterol 14alpha-demethylase, cyp51, cytochrome p450, heme, oxidoreductase, monooxygenase, sterol biosynthesis, lipids, endoplasmic reticulum, iron, heme-thiolate protein |
Biological source | Trypanosoma brucei |
Total number of polymer chains | 4 |
Total formula weight | 208556.45 |
Authors | Lepesheva, G.I.,Hargrove, T.Y.,Harp, J.,Wawrzak, Z.,Waterman, M.R. (deposition date: 2009-03-31, release date: 2009-11-17, Last modification date: 2023-09-06) |
Primary citation | Lepesheva, G.I.,Park, H.W.,Hargrove, T.Y.,Vanhollebeke, B.,Wawrzak, Z.,Harp, J.M.,Sundaramoorthy, M.,Nes, W.D.,Pays, E.,Chaudhuri, M.,Villalta, F.,Waterman, M.R. Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. J.Biol.Chem., 285:1773-1780, 2010 Cited by PubMed: 19923211DOI: 10.1074/jbc.M109.067470 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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